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Hogarth, a 26 year old botanist, has been diagnosed with depression. Reluctant to take prescribed medication he prefers to try alternative medicines which he feels are better for the body and work just as well. You feel that his disorder would improve more effectively with an SSRI, but he feels strongly that St. John's Wort will be equally as effective.
P: adult male with depression
I: SSRI
C: St. John's Wort
O: reduce depressive symptoms
Answerable question: In adult males with depression, are SSRI's more effective than St John's Wort in reducing depressive symptoms?
MeSH: Depressive Disorder/*drug therapy or /*therapy or /*prevention and control; Hypericum/*therapeutic use or /adverse effects; Serotonin Uptake Inhibitors/*therapeutic use or /*adverse effects

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Angela is an otherwise healthy 50 year old woman with early osteoarthritis in her knees, hips, and feet. She has been taking ibuprofen with some relief, but is reluctant to be on longterm medication. She asks you about possibly trying acupuncture for her arthritis; what is your recommendation?
P - middle aged woman with osteoarthritis
I – acupuncture
C – nsaids
O – pain relief